MYC drives resistance to PI3K/mTOR targeted inhibition (gene expression)

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GSE25172

Homo sapiens

9 Downloadable Samples

Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Submitter Supplied Information

Description

Gene expression signatures were measured after treatment of cells with 50nM BEZ235. Affymetrix HG-U133AV2 expression arrays were performed according to the manufacturer's directions using RNA extracted by Qiagen RNeasy from engineered human cell-lines grown for 72h in the presence of 50nM BEZ235

PubMed ID

21876152

Publication Title

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.

Total Samples

Submitter’s Institution

Dana-Farber Cancer Institute

Authors

Ilic N, Utermark T, Widlund HR, Roberts TM

Source Repository

Gene Expression Omnibus (GEO)

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