Expression data from Neuro2a mouse neuroblastoma cell lines, anchorage dependent cells (AD) and anchorage-independent tumorspheres (AI)

The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy is hypothesized to result from a phenomenon known as reversible adaptive plasticity (RAP). RAP is a novel phenomenon enabling neuroblastoma cells to transition between a proliferative anchorage dependent (AD) state and a slow growing anoikis-resistant anchorage independent (AI) state.

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Chakrabarti L, Wang BD, Lee NH, Sandler AD