integrin alpha7 overexpression effects on skeletal muscle transcriptions

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GSE8313

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this study provide insights into the effects of increasing integrin alpha7 expression on skeletal muscle transcription and physiology in vivo. This analysis also evaluates any potential possible side effects associate with enhancing integrin alpha7 in skeletal muscle.

PubMed ID

18045857

Publication Title

Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression.

Total Samples

Submitter’s Institution

University of Illinois at urbana-champaign

Authors

Liu J, Burkin DJ, Kaufman SJ

Source Repository

Gene Expression Omnibus (GEO)

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