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accession-icon GSE55285
Expression data from undifferentiated human ES cell line, khES3, grown using complete, methionine, leucine or lysine deprived media and ES cell derived endoderm
  • organism-icon Homo sapiens
  • sample-icon 7 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE62572
Global gene expression profiling human and Chimpanzee induced pluripotent stem (iPS) cell
  • organism-icon Pan troglodytes, Homo sapiens
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Gene expression study of human and Chimpanzee iPS cell.

Publication Title

New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE55283
Expression data from undifferentiated human ES cell line, khES3, grown using complete or methionine deprived media and ES cell derived endoderm
  • organism-icon Homo sapiens
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

In undifferentiated human ES cells, 5hr Met deprivation (delta Met) led to decreased proliferation, and prolonged 24hr Met deprivation resulted in G0-G1 phase cell cycle arrest, which then led to apoptosis.

Publication Title

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE78797
Expression data from the mouse ES cell-derived differentiated cells treated with or without MPA
  • organism-icon Mus musculus
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Mycophenolic acid (MPA), effectively promoted ES cell pancreatic differentiation with a concomitant reduction of neuronal cells.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE55284
Expression data from undifferentiated human ES cell line, khES3 grown using complete, leucine or lysine deprived media
  • organism-icon Homo sapiens
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

In undifferentiated human ES cells, 48hr Leucine deprivation (delta Leu) or Lysine deprivation (delta Lys) led to apoptosis.

Publication Title

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE55764
Expression data from the transplanted mouse islets into hyperglycemic and normoglycemic mice at 6 hours post-transplantation
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

insulin treatment protects islets from the initial rapid loss that is usually observed after transplantation and positively affects the outcome of islet transplantation in Akita mice.

Publication Title

Beneficial effect of insulin treatment on islet transplantation outcomes in Akita mice.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE109696
ERG and FLI1 in endothelial cells
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE75690
Expression data from CD8alpha positive dendritic cells
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

We screened a number of interferon inducible genes that may be involved in impeding HBV replication and found an anti-HBV activity in ISG20. ISG20 is an IFN-inducible 3- to 5-exonuclease, that degrades DNA and RNA and reduces antigen production in hepatocyte-derived cells

Publication Title

Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.

Sample Metadata Fields

Specimen part, Treatment

View Samples
accession-icon GSE59695
Role of histone lysine demethylase LSD2 in hepatic metabolism
  • organism-icon Homo sapiens
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE43762
Expression profiling of glioma initiating cells (GICs) in the sphere and differentiation conditions
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we established GIC clones from GBM patient tumors having the potential to differentiate into malignant gliomas in mouse intracranial xenograft, and established an in vitro glioma induction system by using serum stimulation.

Publication Title

Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV.

Sample Metadata Fields

No sample metadata fields

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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